Familial Lymphoproliferative Malignancies and Tandem Duplication of NF1 Gene
Background.Neurofibromatosis type 1 ssp218dda-sf is a genetic disorder caused by loss-of-function mutations in a tumor suppressor gene (NF1) which codifies the protein neurofibromin.The frequent genetic alterations that modify neurofibromin function are deletions and insertions.Duplications are rare and phenotype in patients bearing duplication of